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Latest news and research
Read about our past and active projects and how progress is being made toward cures for cancer, lung disease, diabetes and heart disease.
New Strategies For Tackling Triple-Negative Breast Cancer
Research at JAX has uncovered a molecular “fingerprint” that could lead to better outcomes for TNBC patients. JAX Associate Research Scientist Francesca Menghi wants oncologists…
Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes
Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing Francesco Franchi, MD, Fabiana Rollini, MD, Jose Rivas, MD, Andrea Rivas,…
Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention
Footnotes Data sharing: The data, analytic methods, and study materials will not be made available to other researchers for purposes of reproducing the results or…
Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI
Overview Cangrelor is an intravenous P2Y12 inhibitor utilized as a bridge to achieve adequate platelet inhibition until oral P2Y12 inhibitors achieve their full antiplatelet effects…
Scott R. MacKenzie Foundation awards $350,000 in support of two-year clinical trial
Diana Azzam, a researcher in the Robert Stempel College of Public Health & Social Work, will collaborate with Cleveland Clinic Florida on a study to…
Seeing science fiction become reality
As a child growing up in East Millinocket, Maine, Scott MacKenzie was a huge fan of science and science fiction. One of the first magazines…
Clopidogrel drug interactions: a review of the evidence and clinical implications
ABSTRACT Introduction Patients with cardiovascular disease are commonly affected by a number of comorbidities leading to a high prevalence of polypharmacy. Polypharmacy increases the probability…
Evaluating the Extent of Reusability of CYP2C19 Genotype Data among Patients Genotyped for Antiplatelet Therapy Selection
Abstract Purpose. Genotype-guided antiplatelet therapy is increasingly being incorporated into clinical care. The purpose of this study is to determine the extent to which patients…
Acute and Chronic Antithrombotic Therapy in STEMI Patients Undergoing Primary PCI
A review of the anticoagulant and antiplatelet agents currently available for the treatment of STEMI patients undergoing PPCI. Acute ST-segment elevation myocardial infarction (STEMI) comprises…
Mayo Clinic’s Tapestry Study to Collect Genomic Sequencing Data on 100,000 Patients
Initial focus to include familial hypercholesterolemia and hereditary breast and ovarian cancer Collaborating with Helix, a population genomics company, Mayo Clinic said it is creating…
Scientists at MDI Biological Laboratory identify new genetic regulators of regeneration
BAR HARBOR, MAINE — Scientists at the MDI Biological Laboratory and the University of Maine have discovered that genetic material in the cell that was previously thought…
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention
Abstract Background The CYP2C19 nonfunctional genotype reduces clopidogrel effectiveness after percutaneous coronary intervention (PCI). Following clinical implementation of CYP2C19 genotyping at University Florida (UF) Health Shands Hospital in…
High School Summer Fellows Participate in Research at MDI Biological Laboratory
Fellowships Offer Opportunity for Real-World Biomedical Research BAR HARBOR, MAINE — Nine high school students participated in research fellowships at the MDI Biological Laboratory in Bar Harbor, Maine,…