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Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention
Footnotes Data sharing: The data, analytic methods, and study materials will not be made available to other researchers for purposes of reproducing the results or replicating the procedure. https://www.ahajournals.org/journal/circDominick J….
Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI
Overview Cangrelor is an intravenous P2Y12 inhibitor utilized as a bridge to achieve adequate platelet inhibition until oral P2Y12 inhibitors achieve their full antiplatelet effects in patients undergoing coronary stenting….
Scott R. MacKenzie Foundation awards $350,000 in support of two-year clinical trial
Diana Azzam, a researcher in the Robert Stempel College of Public Health & Social Work, will collaborate with Cleveland Clinic Florida on a study to find new treatment options for…
Seeing science fiction become reality
As a child growing up in East Millinocket, Maine, Scott MacKenzie was a huge fan of science and science fiction. One of the first magazines he ever subscribed to was…
Clopidogrel drug interactions: a review of the evidence and clinical implications
ABSTRACT Introduction Patients with cardiovascular disease are commonly affected by a number of comorbidities leading to a high prevalence of polypharmacy. Polypharmacy increases the probability of drug–drug interactions (DDIs). Amongst…
Evaluating the Extent of Reusability of CYP2C19 Genotype Data among Patients Genotyped for Antiplatelet Therapy Selection
Abstract Purpose. Genotype-guided antiplatelet therapy is increasingly being incorporated into clinical care. The purpose of this study is to determine the extent to which patients initially genotyped for CYP2C19 to guide antiplatelet…
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